CASE REPORT A Patient with Chronic Hepatitis C WhoObtained Sustained Response by Retreatment of Interferon after Decrease of Viral Load and Mutation in Interferon Sensitivity Determining Region
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چکیده
A 44-year-old man with chronic hepatitis C received three courses of interferon (IFN) therapy. HCVgenotype was lb, viral load was 1,200 kcopies/ml and interferon sensitivity determining region (ISDR) was the intermediate type before the 1st IFN therapy. The 1st and 2nd IFN therapies resulted in failure to yield a sustained response. Seven years after from the 1st therapy, viral load had decreased to 15 kcopies/ml and ISDR had changed to mutant type. The 3rd IFN therapy yielded sustained response. Thus, we should consider retreatment with IFN whena decrease of the viral load and change of ISDRto mutant type are observed. (Internal Medicine 40: 489-492, 2001) Key wards: direct sequencing, HCV-J, PCR
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